Abstract 1 Trends of IS&T in the First Half of the 21^st Century 1.1 Overall Trends of IS&T 1.2 The Next 20 to 30 Years will be a Period of Transformation and Breakthrough for IS&T 1.3 IT is Entering the Mass Adoption Phase 1.4 IS&T will become the Bond of Various Sciences for Discipline Crossing and Convergence 1.5 Inspiration from the IS&T Strategies of Developed Countries 2 The Strategic Requirements for IS&T in China 2.1 The Status of IS&T Development in China 2.2 Problems and Challenges in the Development of IS&T in China 2.3 Demands for IS&T in China's Economic and Social Development 2.4 Opportunities for Development of IS&T in China 3 Strategic Targets for the IS&T Development 3.1 Overall Objective for the Development of IS&TTo Realize an Information Society 3.2 Basic Framework of IS&T Development up to 2050 3.3 Challenges and Issues in IS&T up to 2050 4 Building an Adequate Information Network 4.1 Target and Roadmap 4.2 Upgrading Communication and Information Networks 4.3 Creating Ubiquitous Sensor Networks and Internet of Things 4.4 Establishing Service Science and Providing Satisfactory Network Services 4.5 Developing the New Information Theory of Network Science 4.6 Achieving Natural and Pervasive Human-Computer Interaction 5 Revolutionary Upgrade of Information Devices and Systems 5.1 Targets and Roadmap 5.2 Three Paths for the Development of Micro-Nano Electronics 5.3 Developing Revolutionary Optoelectronic and Photonic Devices 5.4 Studying General Purpose Quantum Computers and Putting Them to Use 5.5 Beyond Zettaflops (10^21 flops) Supercomputing 6 Developing the Data Knowledge Industry 6.1 Target and Roadmap 6.2 Ultra High Capacity and Low-cost Storage Devices and Systems 6.3 Making Breakthroughs in Semantic Processing 6.4 Contents Computing and Culture Services 7 Facilitating Industry Upgrade,Low Cost Informatization and Sustainable Development 7.1 Target and Roadmap 7.2 Developing Industrial Software and Upgrading Traditional Industries 7.3 Realizing Low-cost and Effective Informatization for the Masses 7.4 Realizing Sustainable Development of the Information Industry 8 Developing New Information Science and Interdisciplinary Sciences Based on Computation 8.1 Target and Roadmap 8.2 New Computation Models,Algorithm Theories,and Fundamental Theories of Software for Trustworthy Computing 8.3 Making Breakthroughs in Intelligence and Cognitive Science 8.4 Promoting Computational Biology as a Main Branch of Life Science 8.5 Promoting Social Computing as an Important Field of Social Sciences 9 Establishing a Technical System for National and Social Information Security 9.1 Target and Roadmap 9.2 Establishing a Basic Technical System for Information Security Based on Cryptographic Techniques 9.3 Establishing a Technical System for Cyberspace Security Based on Supervision Technology 9.4 Establishing a Technical System for Information Security Service Based on Assessment Technology 9.5 Establishing a New Network System with Communication Security Based on Quantum Cryptography References Epilogue