I. Antiviral Research 1.SARS Outbreak and the Diagnostic Technology by Anna M. Zhou 2.SARS Differential Diagnosis with a Bead Array Method by Xu Ma, ZhaoHui Wang, Lisa Varnavas, Christy Teng-Renzelman, Jessie He, ChiungMei Lu, and Jian Han 3.Design of Rhinovirus Protease Inhibitors for Treatment of the Common Cold by Q. May Wang and Shu-Hui Chen 4.Blocking HIV Entry: Discovery and Development of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of HIV Infection by Ruo W. Steensma 5.Nucleoside and Nucleotide Analogs with Therapeutic Potentials for the Treatment of HBV Infection by Tianwei Ma, Yvonne YeeMai Yip, and Shu-Hui Chen 6.HCV Protease Inhibitors as Potential Therapeutic Agents for the Treatment of HCV Infection by Seng-Lai Tan, Frantz Victor, and Shu-Hui Chen 7.Antiviral Agents for Treatment of Herpes by Jian Eric Hong II. Biotechnology and Drug Discovery 1.SUMO: The Proteome’s Little Prince by Kosi Gramatikoff, Chun Wu, Xinying Shi, and Fang Fang 2.Genes Associated with Memory Deficit and Brain Aging by Bing Mei and Yinghe Hu 3.Polyclonal Gene-Specific IgY Antibodies for Proteomics and Abundant Plasma Protein Depletion by Xiangming Fang, Kena W. Curran, Lei Huang, Weiping Xiao, William Strauss, Gulia Harvie, Jerald Feitelson, and Wei-Wei Zhang 4.Use of a-Helix Mimicking Templates for Modulating Protein-Protein Interactions by Justin T. Ernst and Hiroshi Nakanishi 5.Identification of Novel a-Helix Secondary Structure Mimetics by Vincent J. Huber, Min S. Lee, and Hiroshi Nakanishi 6.Targeting Specific Amino Acid Residues in Designing Selective Protein Kinase Inhibitors by Yi Liu and Nathanael Gray 7.RNA Directed Small Molecule Drug Discovery by Baogen Wu and Yun He 8.NMR in Drug Discovery by Xuemei Huang and Min S. Lee 9.FDA New Drug Approvals in 2002 by Boying Guo, Ru Bi, Kang Zhao, and John Reiner