SECTION 1 Genetic Basis of Cancer 1. Structure and Function of the Gene 2. Regulation of the Cell Cycle 3. Cancer Biology: Invasion and Metastasis 4. Genes and Cancer: Risk Determinants and Agents of Change 3. Oncogenes and Tumor Suppressor Genes 6. Molecular Diagnostic Method: in Cancer Genetics 7. Genetics in Clinical Oncology SECTION 2 Immunotogic Basis of Cancer 8. T-Lymphocyte Responses 9. B-Lymphocyte Responses 10. Immunodeficiency and Cancel 11. Tumor Immunology and Immunotherapy 12. New Developmental Therapie; Antiangiogenesis Matrix Metalloproteinases Modulation of Signal Transduction Pathways Antisense Therapeutics SECTION 3 Environmental Basis of Cancer 13. Chemical and Physical Agents in Our Environment 14. Tumor Viruses SECTION 4 Principles of Prevention, Diagnosis, and Therapy 13. Cancer Prevention 16. Economic Analysis of Cancer Treatment 17. Chemotherapy 18. Radiation Therapy 19. Surgical Therapy 20. Bone Marrow Transplantation SECTION 5 Understanding Risk 21. Epidemiology 22. Biostatistics for Clinical Trials