该书是国内第一本有关疼痛学的英文专著,参编着均为工作在第一线的国内外专家和学者,以"实验病理性痛"为中心内容,从病理性痛的神经生物学、病理性痛的神经调节和治疗、人体实验性痛的治疗和神经成像等三个方面系统的阐述了病理性疼痛的发生机制和治疗策略。涵盖了从分子到脑功能、从动物痛到人体实验性痛等广泛地内容。 本书可供生物学、基础医学和临床医学等专业的科研人员以及高年级学生和研究生等参考,对临床医生等也具有较大的参考价值。 Experimental Pathological Pain: From Molecules to Brain Functions is the first academic monograph of English version introducing advancing knowledge about pain mechanisms and its control published by the Chinese publishers. The book is composed of 3 parts (22 chapters): (1) Neurobiology of pathological pain; (2) Neuromodulation of pathological pain and motor dysfunctions; (3) Neuroimaging of experimental human pain. It mainly concentrates on the underlying mechanisms and control strategies of experimental pathological pain with the contents ranging from molecular basis to brain functions and from animals to human beings. The book will be useful to scientific researchers, clinicians, graduate and undergraduate students in the fields of biology, basic medicine and clinical medicine to get good understanding about advances in the study of pain and its management.
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目录
List of Contributing Authors Foreword Ⅰ Foreword Ⅱ Preface Acknowledgments Part Ⅰ Neurobiology of Pathological Pain 1.Genetic Basis of Pain Induction and Modulation 2.Gene Expression in Naturopathic Pain Models 3.Peripheral Mechanisms and Modulation in Inflammatory Pain 4.A Contribution of Dorsal Root Reflexes to Neutrogenic Inflammation and Pain 5.Signal Molecules and Receptors in Primary Afferent Components of Nociceptive Processing and Plastic Changes 6.The Bee Venom Test:A Novel Useful Animal Model for Study of Spinal Coding and Processing of Pathological Pain Information 7.Trigeminal Mechanisms of Orofacial Pain 8.Application of Abult Rat Spinal Slice Patch-clamp Recording Technique in the Study of Nociceptive Transmission and Modulation 9.Temporal Firing Patterns and Responsiveness of Injured Sensory Neurons 10.Temporal Decoding of Persistent Pain Signal Processing in the Spinal Dorsal Horn:Application of Non-linear Dynamic Analytical Methods 11.Thalamo-Cortical System of Nociception in Animals Part Ⅱ Neuromodulation of Pathological Pain and Motor Dysfunctions 12.Physiopharmacological Aspects of Pathological Pain States 13.Novel Pharmacology for Control of Chronic Pain 14.The Roles of 5-HT1A Receptor in Modulating Spinal Nociceptive Transmission in Inflammatory Rats 15.Low- and High-Frequency Electroacupuncture:Difference in Neural Pathways and Therapeutic Effects 16.Restitution of Upper-Limb Movement Promoted with Functional Electrical Therapy(FET) 17.Intranasal Morphine for Pain Manangement Part Ⅲ Neuroimaging of Experimental Human Pain 18.Experimental Human Pain 19.EEG/MEC Brain Mapping of Human Pain 20.Principles of Human Pain Imaging with PET 21.The Application of Source Modelling to Functional Imaging of the Brain Based on EEG and MEG 22.Near-infrared Optical Imaging of the Human Brain