List of Contributors Foreword Preface I. Cell-based Therapeutics 1. Nano-and Micro-Technology to Spatially and Temporally Control Proteins for Neural Regeneration Anjana Jain and Ravi V. Bellamkonda 1.1 Introduction 1.2 Spatially Controlling Proteins 1.3 Temporally Controlling the Release of Proteins 1.4 Conclusion 2. 3-D Fabrication Technology for Tissue Engineering Alice A. Chen，Valerie Liu Tsang，Dirk Albrecht，and Sangeeta N. Bhatia 2.1 Introduction 2.2 Fabrication of Acellular Constructs 2.3 Fabrication of Cellular Constructs 2.4 Fabrication of Hybrid Cell/Scaffold Constructs 2.5 Future Directions 3. Designed Self-assembling Peptide Nanobiomaterials Shuguang Zhang and Xiaojun Zhao 3.1 Introduction 3.2 Peptide as Biological Material Construction Units 3.3 Peptide Nanofiber Scaffold for 3-D Cell Culture，Tissue Engineering and Regenerative Medicine 3.4 Peptide Surfactants/Detergents Stabilize Membrane Proteins 3.5 Perspective and Remarks 4. At the Interface: Advanced Mierofluidie Assays for Study of Cell Function Yoko Kamotani，Dongeun Huh，Nobuyuki Futai，and Shuichi Takayama 4.1 Introduction 4.2 Microfabrication 4.3 Microscale Phenomena 4.4 Examples of Advanced Microfluidic Cellular Bioassays 4.5 Conclusion 5. Multi-phenotypic Cellular Arrays for Biosensing Laura J. Itle，Won-Gun Koh，and Michael V. Pishko 5.1 Introduction 5.2 Fabrication of Multi-Phenotypic Arrays 5.3 Detection methods for cell based sensors 5.4 Current Examples of Multi-Phenotypic Arrays 5.5 Future Work 6. MEMS and Neurosurgery Shuvo Roy，Lisa A. Ferrara，Aaron J. Fleischman，and Edward C. Benzel Part I: Background 6.1 What is Neurosurgery? 6.2 History of Neurosurgery 6.3 Conventional Neurosurgical Treatments 6.4 Evolution of Neurosurgery Part II: Applications 6.5 MEMS for Neurosurgery 6.6 Obstacles to Neurosurgical Employment of MEMS 6.7 Opportunities 6.8 Prospects for MEMS in Neurosurgery II. Drug Delivery 7. Vascular Zip Codes and Nanopartiele Targeting Erkki Ruoslahti 7.1 Introduction 7.2 In vivo Phage Display in Vascular Analysis 7.3 Tissue-Specific Zip Codes in Blood Vessels 7.4 Special Features of Vessels in Disease 7.5 Delivery of Diagnostic and Therapeutic Agents to Vascular Targets 7.6 Homing Peptides for Subcellular Targeting 7.7 Nanoparticle Targeting 7.8 Future Directions 8. Engineering Biocompatible Quantum Dots for Ultrasensitive,Real-Time Biological Imaging and Detection Wen Jiang，Anuparn Singhal，Hans Fischer，Sawitri Mardyani，and Warren C. W. Chan 8.1 Introduction 8.2 Synthesis and Surface Chemistry 8.3 Optical Properties 8.4 Applications 8.5 Future Work 9. Diagnostic and Therapeutic Applications of Metal Nanoshells Leon R. Hirsch，Rebekah A. Drezek，Naomi J. Halas，and Jennifer L. West 9.1 Metal Nanoshells 9.2 Biomedical Applications of Gold Nanoshells 10. Nanoporous Mierosystems for Islet Cell Replacement Tejal A. Desai，Teri West，Michael Cohen，Tony Boiarski，and Arfaan Rampersaud 10.1 Introduction 10.2 Fabrication of Nanoporous Membranes 10.3 Biocapsule Assembly and Loading 10.4 Biocompatibility of Nanoporous Membranes and Biocapsular Environment 10.5 Microfabricated Biocapsule Membrane Diffusion Studies 10.6 Matrix Materials Inside the Biocapsule 11. Medical Nanoteehnology and Pulmonary Pathology Amy Pope-Harman and Mauro Ferrari 11.1 Introduction 11.2 Current Applications of Medical Technology in the Lungs 11.3 Potential uses of Nanotechnology in Pulmonary Diseases 11.4 Conclusion 12. Nanodesigned Pore-Containing Systems for Biosensing and Controlled Drug Release Frederique Cunin，Yang Yang Li，and Michael J. Sailor 12.1 System Design Considerations 12.2 Porous Material-Based Systems 12.3 Silicon-Based Porous Materials 12.4 "Obedient" Materials 12.5 Porous Silicon 12.6 Templated Nanomaterials 12.7 Photonic Crystals as Self-Reporting Biomaterials 12.8 Using Porous Si as a Template for Optical Nanostructures 12.9 Outlook for Nanotechnology in Pharmaceutical Research 13，Transdermal Drug Delivery using Low-Frequency Sonophoresis Samir Mitragotri 13.1 Introduction 13.2 Ultrasound in Medical Applications 13.3 Sonophoresis: Ultrasound-Mediated Transdermal Transport 13.4 Low-Frequency Sonophoresis 13.5 Low-Frequency Sonophoresis: Choice of Parameters 13.6 Macromolecular Delivery 13.7 Transdermal Glucose Extraction Using Sonophoresis 13.8 Mechanisms of Low-Frequency Sonophoresis 13.9 Conclusions 14. Mierodeviees for Oral Drug Delivery Sarah L. Tao and Tejal A. Desai 14.1 Introduction 14.2 Materials 14.3 Microfabrication 14.4 Surface Chemistry 14.5 Surface Characterization 14.6 Miocrodevice Loading and Release Mechanisms 15. Nanoporous Implants for Controlled Drug Delivery Tejal A. Desai，Sadhana Sharma，Robbie J. Walczak，Anthony Boiarski, Michael Cohen，John Shapiro，Teri West，Kristie Melnik，Carlo Cosentino, Piyush M. Sinha，and Mauro Ferrari 15.1 Introduction 15.2 Fabrication of Nanoporous Membranes 15.3 Implant Assembly and Loading 15.4 Nanoporous Implant Diffusion Studies 15.5 Biocompatibility of Nanoporous Implants 15.6 Conclusions III. Molecular Surface Engineering for the Biological Interface 16. Micro and Nanoscale Smart Polymer Technologies in Biomedicine Samarth Kulkarni，Noah Malmstadt，Allan S. Hoffman，and Patrick S. Stayton 16.1 Smart Polymers 16.2 Smart Meso-Scale Particle Systems 16.3 Smart Bead Based Microfluidic Chromatography 17. Supported Lipid Bilayers as Mimics for Cell Surfaces Jay T. Groves 17.1 Introduction 17.2 Physical Characteristics 17.3 Fabrication Methodologies 17.4 Applications 17.5 Conclusion 18. Engineering Cell Adhesion Kiran Bhadriraju，Wendy Liu，Darren Gray，and Christopher S. Chen 18.1 Introduction 18.2 Regulating Cell Function via the Adhesive Microenvironment 18.3 Controlling Cell Interactions with the Surrounding Environment 18.4 Future Work 18.5 Conclusions 19. Cell Biology on a Chip Albert Folch and Anna Tourovskaia 19.1 Introduction 19.2 The Lab-on-a-chip Revolution 19.3 Increasing Experimentation Throughput 19.4 Increasing the Complexity of the Cellular Microenvironment 19.5 Conclusion About the Editors Index
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