Contributors Preface 1.Extracellular Dynamics at nm Resolution in Live Cells Bhanu P.Jena I.Introduction II.Materials and Methods III.Conclusion References 2.Intracellular Organelle Dynamics at nm Resolution Bhanu P.Jena I.Introduction II.Materials and Methods III.Discussion References 3.Atomic Force Microscopy as a Tool to Study the Proteasome Assemblies Maria Gaczynska and Pawel A.Osmulski I.Introduction II.Rationale III.Methods IV.Discussion V.Summary References 4.Biomineralization at the Nanoscale: Learning from Diatoms David P.Allison, Yves F.Dufrene, Mitchel J.Doktycz, and Mark Hildebrand I.Introduction to Nanotechnology II.Introduction to Diatoms III.Investigating Diatom Mesoscale Silica Formation IV.Nanoscale Imaging of Living Diatoms V.Nanoscale Elasticity Measurements VI.Examination of Diatom Valves VII.Examination of Diatom Girdle Bands VIII.Examination of Diatom Setae IX.Future Directions References 5.Quantitative Phase Imaging of Nanoscale Cell Structure and Dynamics Gabriel Popescu I.Introduction and Rationale II.Methods III.Applications of QPI IV.Summary and Outlook References 6.Fourier Imaging Correlation Spectroscopy for Cellular Structure-Function Eric N.Senning, Geoffrey A.Lott, and Andrew H.Marcus I.Introduction and Background II.Theoretical Descriptions of FICS III.FICS Optical Layout IV.Examples of FICS Applications V.Conclusions References 7.Nanobiology of the Primary Cilium-Paradigm of a Multifunctional Nanomachine Complex Denys N.Wheatley I.Introduction II.Self-Assembly III.Ciliogenesis IV.Elucidating the Functional Role of Primary Cilia V.The Medical Consequences of Aciliogenesis-A Veritable Pandora's Box VI.Concluding Remarks References 8.Assembly and Disassembly of SNAREs in Membrane Fusion Bhanu P.Jena I.Introduction II.Materials and Methods III.Discussion References 9.Understanding Membrane Fusion: Combining Experimental and Simulation Studies Bhanu P.Jena I.Introduction II.Materials and Methods III.Materials and Methods References 10.Structure and Dynamics of Metalloproteins in Live Cells Jeremy D.Cook, James E.Penner-Hahn, and Timothy L.Stemmler I.Introduction II.Rationale III.Methods IV.Materials V.Discussion VI.Summary References 11.Light-Activated Ion Channels for Remote Control of Neural Activity James J.Chambers and Richard H.Kramer I.Introduction II.Discussion III.Methods IV.Conclusion References 12.Molecular Modeling and Simulation Studies of Ion Channel Structures, Dynamics and Mechanisms Kaihsu Tai, Philip Fowler, Younes Mokrab, Phillip Stansfeld, and Mark S.P.Sansom I.Introduction II.Homology-Based Structure Prediction of Transmembrane Proteins III.PB Profiles for the Energetics of an Ion in a Channel IV.MD Simulations V.Free Energy Methods VI.Summary References 13.Nano-Scale Imaging and Dynamics of Amylin-Membrane Interactions and Its Implication in Type II Diabetes Mellitus Won-Jin Cho, Bhanu P.Jena, and Aleksandar M.Jeremic I.Introduction II.Materials and Methods III.Results and Discussion IV.Summary References 14.Real Time Investigation of Protein Folding, Structure, and Dynamics in Living Cells Qianqian Li, Yuefei Huang, Nan Xiao, Victoria Murray, Jianglei Chen, and Jianjun Wang I.Introduction II.Rationale III.Methods and Materials IV.Summary References 15.Structural Basis of Human High-density Lipoprotein Formation and Assembly at Sub nanometer Resolution Arun Sivashanmugam, Yunhuang Yang, Victoria Murray, Christopher McCullough, Bin Chen, Xuefeng Ren, Qianqian Li, and Jianjun Wang I.Introduction II.Rationale III.Methods and Materials IV.Discussion V.Summary References 16.Nano-scale Characterization of the Dynamics of the Chloroplast Toc Translocon L.Evan Reddick, Prakitchai Chotewutmontri, Will Crenshaw, Ashita Dave, Michael Vaughn, and Barry D.Bruce I.Introduction II.In organeller Chloroplast Import and Binding Assays III.Toc Translocon Dynamics IV.Activity and Enzymology of Toc GTPases V.Molecular Modeling of Toc Proteins VI.Conclusions and Perspectives References 17.A System Biology Approach to Understand Functional Activity of Cell Communication Systems Julio Vera and Olaf Wolkenhauer I.Introduction II.Methods III.Materials IV.Discussion References 18.THz Investigations of Condensed Phase Biomolecular Systems Hailiang Zhang, Karen Siegrist, Kevin O.Douglas, Susan K.Gregurick, and David F.Plusquellic I.Introduction II.Instrumentation III.Theory IV.Dipeptides Nanotubes References 19.Combined Single-Molecule Electrical Recording and Single-Molecule Spectroscopy Studies of Ion Channel Conformational Dynamics H.Peter Lu I.Introduction II.Development of Simultaneous Single-Molecule Fluorescence Spectroscopy and Patch-Clamp Electrical Recordings III.Summary and Prospects References Index
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