Abbreviations Preface Section A-Cells and macromolecules A1 Cellular classification A2 Subcellular organelles A3 Macromolecules A4 Large macromolecular assemblies Section B-Protein structure B1 Amino acids B2 Protein structure and function B3 Protein analysis Section C-Properties of nucleicacids C1 Nucleic acid structure C2 Chemical and physical properties of nucleic acids C3 Spectroscopic and thermal properties of nucleic acids C4 DNA supercoiling Section D-Prokaryotic and eukaryotic chromosome structure D1 Prokaryotic chromosome structure D2 Chromatin structure D3 Eukaryotic chromosome structure D4 Genome complexity Section E-DNA replication E1 DNA replication:an overview E2 Bacterial DNA replication E3 Eukaryotic DNA replication Section F-DNA damage,repair and recombination F1 Mutagenesis F2 DNA damage F3 DNA repair F4 Recombination Section G-Gene manipulation G1 DNA cloning:an overview G2 Preparation of plasmid DNA G3 Restriction enzymes and electrophoresis G4 Ligation,transformation and analysis of recombinants Section H-Cloning vectors H1 Design of plasmid vectors H2 Bacteriophage vectors H3 Cosmids and YACs H4 Eukaryotic vectors Section I-Gene libraries and screening I1 Genomic libraries I2 CDNA libraries I3 Screening procedures Section J-Analysis and uses of cloned DNA J1 Characterization of clones J2 Nucleic acid sequencing J3 Polymerase chain reaction J4 Organization of cloned genes J5 Mutagenesis of cloned genes J6 Applications of cloning Section K-Transcription in prokaryotes K1 Basic principles of transcription K2 Escherichia coli RNA polymerase K3 The E.coli σ70promoter K4 Transcription initiation,elongation and termination Section L-Regulation of transcription in prokaryotes L1 The lac operon L2 The trp operon L3 Transcriptional regulation by alternative σfactors Section M-Transcription in eukaryotes M1 The three RNA polymerases:characterization and function M2 RNA Pol I genes:the ribosomal repeat M3 RNA Pol III genes:5S and tRNA transcription M4 RNA Pol II genes:promoters and enhancers M5 General transcription factors and RNA Pol II initiatio Section N-Regulation of transcription in eukaryotes N1 Eukaryotic transcription factors N2 Examples of transcriptional regulation Section O-RNA processing and RNPs O1 rRNA processing and ribosomes O2 tRNA processing,RNase P and ribozymes O3 mRNA processing,hnRNPs and snRNPs O4 Alternative mRNA processing Section P-The genetic code and tRNA P1 The genetic code P2 tRNA structure and function Section Q-Protein synthesis Q1 Aspects of protein synthesis Q2 Mechanism of protein synthesis Q3 Initiation in eukaryotes Q4 Translational control and post-translational events Section R-Bacteriophages and eukaryotic viruses R1 Introduction to viruses R2 Bacteriophages R3 DNA viruses R4 RNA viruses Section S-Tumor viruses and oncogenes S1 Oncogenes found in tumor viruses S2 Categories of oncogenes S3 Tumor suppressor genes Further reading Index
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