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磁场与生命科学的跨学科研究（英文版）


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磁场与生命科学的跨学科研究（英文版）
  • 书号：9787030599100
    作者：无
  • 外文书名：
  • 装帧：圆脊精装
    开本：B5
  • 页数：443
    字数：无
    语种：en
  • 出版社：科学出版社
    出版时间：1900-01-01
  • 所属分类：
  • 定价： ￥249.00元
    售价： ￥196.71元
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本书共分16章,介绍了磁场和生命科学在中国的跨学科研究。本书作者来自中国科学院，中国科技大学，厦门大学，浙江大学，东南大学，西北工业大学，南京大学等多个科研机构。本书涵盖了关于磁场与生命科学交叉学科研究的各种主题，包括磁性纳米粒子及其潜在的医疗应用，静态和低频磁场的生物效应及其潜在的临床应用，技术和应用的核磁共振（NMR）和磁共振成像（MRI）在生命科学研究。重点介绍了中国学者近年来的研究进展，同时也包括了国外学者的一些研究进展。

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目录

  • Contents
    Foreword
    Preface
    Section I Magnetic Fields and Their Biological Effects
    Chapter I Medical Theranostics Based on Iron Oxide Nanoparticles under Magnetic Fields 3
    1.1 Introduction 3
    1.2 Propcrties of IONPs under magnetic ficlds 4
    1.3 Pharmacokinetic and biocompability 5
    1.4 Contrast agcnts of MRI 7
    1.5 Hyperthermal agents 8
    1.6 Drug delivcry systcms 12
    1.7 Multimodality theranostics systems of magnetic microbubbles, microcapsules and liposomes 13
    1.8 0ther thcrapeutic potcntials 17
    1.9 Summary and future prospective 20
    Rcfercnccs 21
    Chapter 2Progress of Static Magnetic Fields and Cancer Research in China 31
    2.1 Initial clinical studics showcd that SMFs could inhibit cancor growth in some patients 34
    2.2 Ccllular studics show that SMF inhibits multiplc canccr ccll growth but has minimum effects on non-cancer cells 36
    2.3 Mcchanisms of canccr inhibition by SMFs studicd at molccular, ccllular and animal levels 37
    2.4 SMF in combination with chemodrugs 48
    2.5 Paramctcrs that dircctly affoct the outcomcs of SMF cxposurc 50
    References 54
    Chapter 3Study of SMF's Effects on Cells: Microorganisms: Animals and Plants in NPU 61
    3.1The offccts of SMFs on cclls 62
    3.2 The effects of SMFs on microorganism 72
    3.3 The cffbcts of SMF on small animals 74
    3.4 The effects of SMFs on plants 78
    Rcfcronccs 80
    Chapter 4In Vitro Cellular Response to ELF-MF and RF-EMF 83
    4.1 Gap junctional intercellular communication 85
    4.2 Epidcrmal growth factor rccoptor (EGFR) clustoring 88
    4.3 Stress kinases signaling in response to ELF-MF 91
    4.4 Efrcct of ELF-MF and RF-EMF on gonc cxprcssion 92
    4.5 Effect of ELF-MF and RF-EMF on protein expression 95
    4.6 DNA damage response to EMF exposure 97
    Rcfcrcncos 100
    Chapter 5Utilization of Magnetic Field for Protein Crystallization 108
    5.1 Introduction 109
    5.2 Effocts of magnotic fiold on protcin crystallization 117
    5.3 Quality of protoin crystals obtainod in the magnctic ficld 125
    5.4 Toward applications in practical protein crystallization 133
    5.5 Concluding rcmarks and futurc pcrspcctives 135
    References 136
    Chapter 6High Static Magnetic Fields (SMFs) on Reproduction and Development of an Intact Living Organism: Caenorhabditiselegans 144
    6.1Caenorhabditis elegans (C. eleqans) and its rosponsc to magnctic field 146
    6.2 Sourco of high SMF and oxposurc proccdurcs 148
    6.3 SMFs on the lifespan and development process of C. elega'ns 149
    6.4 SMF on brood sizc and gcrmline apoptosis in C. elega'ns 151
    6.5SMF on mitochondrial damage and oxidatiw stress in C.elegans 156
    References 159
    Chapter 7Low FYequency Magnetic Field Regulates Immunity and Inhibits Cancer 164
    7.1 Low frcquency magnotic ficld (LF-MF) oxposure systcm 164
    7.2 Screening for suitable tumor parameters of LF-MF 166
    7.3 Tumor inhibition cffbct of LF-MF 167
    7.4 LF-MF modulated the function of immune system 181
    7.5 LF-MF inhibited adipogenesis of human mesenchymal stem cells 192
    7.6 Research progress of MF in China 197
    7.7 Summary 202
    References 202
    Chapter 8Moderate Intensity Rotating Low Frequency Magnetic Fields and Their Effects on Human Bodies 210
    8.1 MIR-LF-MF with different parameters 211
    8.2 MIR-LF-MF effects on healthy volunteers 214
    8.3 MIR-LF-MF and high-altitude polycythemia (HAPC) 215
    8.4 MIR-LF-MF effects on patients with chronic diseases 216
    8.5 MIR-LF-MF effects on cancer patients 217
    8.6 General effects of MIR-LF-MR on human bodies and working hypothesis 220
    8.7 Conclusions and perspectives 222
    References 222
    Chapter 9 Advances in Static Magnetic Field Safety Studies 224
    9.1 Laboratory studies with cells 225
    9.2 Laboratory studies with animals 227
    9.3 SMF studies with humans 229
    9.4 Epidemiological studies 231
    References 232
    Section 2Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)
    Chapter 10 Structural Basis of Biomolecular Interactions Studied by NMR Spectroscopy 243
    10.1 Expcrimcntal considcrations of NMR-basod structural studics 244
    10.2 Proteins related to regulation of gene expression 245
    10.3 Proteins in cell junction 255
    10.4 NMR mcthodology dcvclopmcnt for macromolccular structurc and dynamics 257
    10.5 NMR application in fragmcnt-bascd lcad discovcry 259
    10.6 Summary and outlook 261
    Rcfcronccs 261
    Chapter 11Protein NMR Spectroscopy in Cell-like Environment 268
    11.1 The effect of macromolecular crowding on protein structure and function 269
    11.2 The effect of confinement on protein structure and function 274
    11.3 Protoin cnrichment in living cells 278
    11.4 Isotopic labeling for protein NMR in cells 279
    11.5 Protein structure and conformation in living cells 280
    11.6 Protein dynamics and intoractions in living cells 287
    11.7 Perspective 296
    Rcfcronccs 296
    Chapter 12High-resolution Nuclear Magnetic Resonance Techniques under Inhomogeneous Magnetic Fields 303
    12.1 Introduction 304
    12.2 IMQC-based high-resolution NMR 305
    12.3 SQC-bascd high-rcsolution NMR 332
    References 346
    Chapter 1319F Nuclear Magnetic Resonance/Magnetic Resonance Imaging in China 355
    13.1 Introduction 356
    13.2 Single-modality probes 356
    13.3 Dual-modality probes 363
    13.4 Multi-modality probos 366
    13.5 0thers 369
    13.6 Conclusions and futurc prospccts 371
    Rcfcronccs 371
    Chapter14Ultrasensitive Xenon MRI and Molecular Imaglng 375
    14.1 Ultrasensitive pulmonary gas magnetic resonance iInaglIlg 376
    14.2 Ultrascnsitivc HP 129Xc NMR probcs 381
    14.3 Microenvironment responsive probes 391
    14.4 Ultralow ficld magnctic rcsonanco spoctroscopy 397
    References 399
    Chapter 15NMR Applications in Measuring Protein Noncovalent Interactions 402
    15.1 h-bond interaction 403
    15.2 C-H/兀 intcraction 407
    15.3 Electrostatic interaction 408
    15.4 Elcctric ficld 411
    References 415
    Chapter 16Application of Nanodiscs in Examining Protein-Membrane Interaction 418
    16.1 Introduction to nanodiscs 418
    16.2 Sclf-asscmbly of nanodiscs 421
    16.3 Properities of naiiodiscs 423
    16.4 Application of nanodiscs for studics of mcmbrano protcins 424
    Rcforonccs 435
    Index 442
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