Preface 1 Epigenetics: From Phenomenon to Field, Daniel E. Gottschling 2 A Brief History of Epigenetics, Gary Felsenfeld 3 Overview and Concepts, C. David Allis, Thomas Jenuwein, and Danny Reinberg 4 Epigenetics in Saccharomyces cerevisiae, Michael Grunstein and Susan M. Gasser 5 Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila, Sarah C.R. Elgin and Gunter Reuter 6 Fungal Models for Epigenetic Research: Schizosac- charomyces pombe and Neurospora crassa, Robin C. Allshire and Eric U. Selker 7 Epigenetics of Ciliates, Eric Meyer and Douglas L. Chalker 8 RNAi and Heterochromatin Assembly, Robert Martienssen and Danesh Moazed 9 Epigenetic Regulation in Plants, Marjori Matzke and Ortrun Mittelsten Scheid 10 Chromatin Modifications and Their Mechanism of Action, Tony Kouzarides and Shelley L. Berger 11 Transcriptional Silencing by Polycomb Group Proteins, Ueli Grossniklaus and Renato Paro 12 Transcriptional Regulation by Trithorax Group Proteins, Robert E. Kingston and John W. Tamkun 13 Histone Variants and Epigenetics, Steven Henikoff and M. Mitchell Smith 14 Epigenetic Regulation of Chromosome Inheritance, Gary H. Karpen and R. Scott Hawley 15 Epigenetic Regulation of the X Chromosomes in C. elegans, Susan Strome and William G. Kelly 16 Dosage Compensation in Drosophila, John C. Lucchesi and Mitzi I. Kuroda 17 Dosage Compensation in Mammals, Neil Brockdorff and Bryan M. Turner 18 DNAMethylation in Mammals, En Li and Adrian Bird 19 Genomic Imprinting in Mammals, Denise P. Barlow and Marisa S. Bartolomei 20 Germ Line and Pluripotent Stem Cells, M. Azim Surani and Wolf Reik 21 Epigenetic Control of Lymphopoiesis, Meinrad Busslinger and Alexander Tarakhovsky 22 Nuclear Transplantation and the Reprogramming of the Genome, Rudolf Jaenisch and John Gurdon 23 Epigenetics and Human Disease, Huda Y. Zoghbi and Arthur L. Beaudet 24 Epigenetic Determinants of Cancer, Stephen B. Baylin and Peter A. Jones Appendices 1 WWW Resources, 2 Histone Modifications and References, Index,