中文摘要 疾病机理 Mechanisms and inhibition of HIV integration Christophe Marchand, Allison A. Johnson, Elena Semenova and Yves Pommier HIV整合的机制和抑制作用 Overcoming HIV-1 resistance to protease inhibitors Ernesto Freire 克服HIV-1对蛋白酶抑制剂的耐药性 Mechanisms of bacterial protein toxin entry into the target cell cytosol John R. Murphy and Robert J. Harrison 细菌毒素进入靶细胞质的机制 Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis? Helena I. Boshoff and Clifton E. Barry III 分支杆菌细胞壁无望成为潜伏性结核病的药物靶点? Tumor necrosis factor-αinhibitors and granulomatous infectious George S. Deepe, Jr and Robert S. Wallis 肿瘤坏死因子α抑制剂和肉芽肿侵染 Could rheumatoid arthritis have an infectious aetiology? Andrew R. Mackenzie and Janet Dawson 类风湿关节炎有传染性病因? Mechanisms of inflammatory response syndrome in sepsis Laszlo M. Hoesel and Peter A. Ward 败血病的炎症反应综合征产生机制 疾病模型 Models of cryptococcal meningitis Robert A. Larsen, Madeline Bauer, Ann M. Thomas and Alejandro Sanchez 隐球菌性脑膜炎模型 Models for the study of respiratory syncytial virus infection and disease James M. Stark 呼吸道合胞体病毒感染病的研究模型 Can animal models predict protection provided by meningococcal vaccines? Michelle Finney, Denise Halliwell and Andrew R. Gorringe 动物模型能够预测流脑菌苗的保护作用? Models of CMV infection Katherine K. Wynn and Rajiv Khanna 巨细胞病毒感染模型 Models of HIV-1 disease: A review of current status Cheryl A. Stoddart and Richard A. Reyes HIV-1疾病模型的现状综述 Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection P. Ling Lin, Denise Kirschner and JoAnne L. Flynn 模型病理和宿主: 潜伏结核分枝杆菌感染的体外、体内和虚拟模型 Advances in viral respiratory infections: new experimental models Lida Mohtasham, Alexander Auais and Giovanni Piedimonte 病毒呼吸道感染进展:新的实验模型 Models of HIV infection utilizing transgenic and reconstituted immunodeficient mice Seth H. Pincus 利用转基因和重建免疫缺陷小鼠制备HIV感染模型 Experimental disease models of influenza virus infections: recent developments Robert W. Sidwell and Donald F. Smee 流感病毒感染实验疾病模型的最新进展 Models for bacterial infectious diseases: Helicobacter pylori Paolo Ruggiero, Ali Alloueche, Rino Rappuoli and Giuseppe Del Giudice 幽门螺旋杆菌感染性疾病模型 技术 Techniques used for the discovery of therapeutic compounds: the case of SARS Shuai Chen, Lili Chen, Kaixian Chen, Xu Shen and Hualiang Jiang 治疗性化合物的发现技术:SARS案例 Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models N. Joan Abbott 药物发现过程中药物透过血脑屏障的体内体外和计算机预测方法 治疗策略 Meningococcal diseases: From genomes to vaccines Laura Serino, Stefania Bambini, Maurizio Comanducci, Mariagrazia Pizza and Rino Rappuoli 脑膜炎球菌病:从基因组到疫苗 Overcoming the problem of chronic hepatitis B James Fung, Ching-Lung Lai and Man-Fung Yuen 攻克慢性乙型肝炎的难题 Progress in antifungal therapy: Echinocandins versus azoles Michael D. Nailor and Jack D. Sobel 抗真菌治疗的进展:棘球白素与唑类比较