Section 1Fundaments of Immunology Chapter 1hnmunity Innate Immunity Adaptive Immunity Chapter 2Immune Cells Phagocytes Lymphocytes Antigen Presenting Cells Chapter 3Lymphoid Tissues and Organs Primary Lymphoid Organs Secondary (peripheral) Lymphoid Tissues and Organs Lymphocyte Traffic and Recirculation Chapter 4Pathological Immunity and Immune Diseases Section 2Brief History and Prospect of Immunology Chapter 1Empirical Immunology Chapter 2Scientific Immunology Discovery of Pathogens and Application of Vaccines Discovery and Application of Antibodies Cellular Immunity Immunological Tolerance Burnet\' s Clonal Selection Theory Chapter 3Modern Immunology Diversity of Antigen Receptors Discovery of Signal Transduction Pathway Discovery of Programmed Cell Death Hematogenesis and Development of Immune Cells Immunological Application Prospect of Immunology IMMUNE MOLECULES Section 3Antigen Chapter 1Properties of Antigen Chapter 2Characteristics of Antigen Chapter 1Introduction Component of Complement System Nomenclature Chapter 2Pathways of Complement Activation Classical Pathway The Lectin Pathway Alternative Pathway Terminal Sequence and the Membrane Attack Complex Chapter 3Regulation of Complement System Activation Self-regulation Fluid-Phase Regulator Solid-Phase Regulator Chapter 4Biological Consequences of Complement Activation Cell Lysis Opsonization and Phagocytosis Viral Neutralization Inflammation Regulation of Cells Clearance of Imnmne Complex Section 6Cytokines Chapter 1Introduction Chapter 2Classification and Biological Activities of Cytokines Interleukins Tumor Necrosis Factor Interferon Hematopoietic ColonyStimulating Factors Transforming Growth Factor Chemokines Chapter 3Cytokine Receptors IL-1 Receptor TNF-o~ Receptors 1L-2 Receptor Chemokine Receptor Chapter 4Clinical Application Section 7Major Histocompatible Complex Chapter 1Structure and Genetics of MHC Classical MHC Gene Complex MHC Molecules Other MHC Genes Chapter 2MHC Polymorphism Concept of Polymorphism Linkage Disequilibrium and Haplotype Generation and Significance of MHC Polymorphism Chapter 3PeptideMHC Interaction Molecular Basis Characteristics Chapter 4I4[A and Clinical Medicine HLA and Graft Rejection HLA Related-Diseases HLA and Diseases Section 8Leukocyte Differentiation Antigens and Adhesion Molecules Chapter 1Leukocyte Differentiation Antigens Concept of Leukocyte Differentiation Antigens Concept of Cluster of Differentiation Chapter 2Cell Adhesion Molecules lntergrin Family Selectin Family Immunoglobulin Superfamily Functions of Cell Adhesion Molecules Chapter 3Clinical Application of CD Mole- cules, Cam and Monoclonal Antibodies Against CD Molecules and Cam Elucidation of Pathogenesis Diagnosis and Prognosis in Clinical Use Prevention and Treatment for Diseases IMMUNE CELLS Section 9Hematopoietic Stem Cells Chapter 1Origin and Surface Markers of Hematopoietie Stem Cells Origin of Hematopoietic Stem Cells Surface Markers of Hematopoietic Stem Cells Chapter 2Differentiation of Hematopoietie Stem Cells The Factors Affect Differentiation of Hematopoietic Stem Cells Development of Lineage-Committed Progenitors Section 10Cells of Innate Immunity Chapter 1Phase of Innate Inmmnity Chapter 2Cells of Innate Innnunity Epithelials Phagocytes Neutrophils Mononuclear Phagocytes: the MonocyteMacrophage System NK Cells Cells B1 B Ceils NK T Cells Chapter 3Receptors of Innate Ceils Pattern-Recognition Receptors Toll Like Receptors Section 11T Lymphoeytes Chapter 1T Cell Ontogeny Stages of Thymocyte Development Positive and Negative Selection of Thymocytes Chapter 2Surface Proteins of T Lymphocytes TCR-CD3 Complex CD4 and CD8 Coreceptors Costimulatory Molecules Mitogen Receptors Chapter 3T Lymphocytes Subsets and Functions Helper T Lymphocytes Cytotoxic T Lymphocytes Memory T Cells Regulatory T Cells Section 12B Lymphoeytes Chapter 1Development of B Lymphocytes The B Cells Development in the Bone MalTow The B Cells Maturation in Germinal Centers Chapter 2Surface Markers of B Lympho cytes BCR Complex Surrogate BCR Complex Other Surface Markers Chapter 3Subsets and Functions of B Lymphocytes B1 Cells and Their Functions B2 Cells and Their Functions Immune Regulation Section 13Organization and Diversity of Antigen Receptor Genes Chapter 1Structure of Antigen Receptor Genes The Gene Structure of BCR The Gene Structure of TCR Chapter 2Rearrangement of Antigen Receptor Genes Chapter 3The Diversity Antigen Receptor Genes BCR TCR IMMUNE RESPONSE Section 14Innate Immune Response Chapter 1Components Involved in Innate Immune Response The Skin and the Mucosal Surfaces Immune Cells Involved in Innate Immune Response Humoral Proteins of Innate Immunity Chapter 2The Recognition Mechanism of Innate Immune Response Pathogen Associated Molecular Pattersn (PAMPs) Pattern Recognition Receptor (PRR) Chapter 3The Biological Significance of Innate Immune Response Section 15Antigen Presentation Chapter 1Antigen Presenting Cells MPS Antigen Processing and Presentation by Dendritic Cells Antigen Processing and Presentation by B Lymphocytes Chapter 2Antigen Processing and Presentation Processing of Exogenous and Endogenous Antigens MHC and Antigen Processing and Presentation CD1 Related Antigen Presentation Section 16T Cells Recognitions and Responses of Antigens Chapter 1T Cells Recognition of Antigens Chapter 2Siguals for T Cells Activation Stimulators of T Cells Activation Double Signals for T Cells Activation Chapter 3Signal Transduction of T Cell Activation Receptor Cross-Iinking Cytoplamic Signaling by TCR Chapter 4Transcription Factor Activation and Gene Expression Chapter 5Functions of Effeetor T Cells Functions of CD4 + TH 1 Cells Functions of CD8 + Cytotoxie T Cells Section 17B Cell Recognition and Resp onse of Antigens Chapter 1B Cell Response to T Cell Dependent Antigen Clonal Selection and Antigen Recognition of B Cells Signaling by BCR Complex and B Cell Coreceptors Effects of T~ Cells and Interaction Between TH and B Cells Development and Differentiation of B Cells in Germinal Centers Chapter 2B Cell Response to T Cell Independent-Antigen B Cell Response to Type 1 of TI Anti gens B Cell Response to Type 2 of TI Anti gens Chapter 3Rules of Antibody Production Immunoglobulin Secretion Primary and Secondary Response Chapter 4Mucosal Immune Response Mucosa-Associated Lymphoid Tissue..- Secretory Ig and Transcytosis Section 18Immunoregulation Chapter 1Role of Antigen, Antibody and Complement Role of Antigen Role of Antibody Role of Complement Chapter 2Role of Signaling Components and Molecules Role of Activating Signaling Components and Molecules Role of Suppressing Signaling Components and Molecules Chapter 3Role of Ceils Role of T Cell Subtypes Role of the Idiotypic Network Role of Apoptosis Chapter 4Neuroendocrine Immune System Regulation Role of Neuroendocrine System Immunoregulation Among Population Section 19Immune Tolerance Chapter 1The Development and Repre sentation of Immune Tolerance Innate Tolerance Acquired Tolerance Chapter 2Mechanisms of Immune Tole rance Central Tolerance Peripheral Tolerance Chapter 3Immune Tolerance and ClinicalMedicine Establishment and Maintenance of Immune Tolerance Abrogation of Immune Tolerance CLINICAL IMMUNOLOGY Section 20Hypersensitivity Chapter 1Type I Hypersensitivity Component and Cells Immune Pathogenesis Type I Hypersensitivity-Associated Diseases Therapy for Type I Hypersensitivity Chapter 2Type II Hypersensitivity Immune Pathogenesis Type II Hypersensitivity-Associatet Diseases Chapter 3Type III Hypersensitivity Immune Pathogenesis Type III Hypersensitivity-Associated Diseases Chapter 4Type IV Hypersensitivity Immune Pathogenesis Diseases caused by Delayed-Type persensitivity Section 21Autoimmunity and Autoimmune Diseases Chapter 1Introduction Autoimmunity Autoimmunc Disease Classification Characteristics Chapter 2Immunologic Pathogenesis and Typical Diseases Autoantibodies Directly Mediated Tissue Damage Autoantibodies Modulate Cell Function Autoantibodies form Damaging Immune Complexes Cell Mediated Immunity in Pathogenesis Chapter 3Factors in Development of Autoimmune Autoantigens Abnormal Immunoregulation Abnormal Expression of Fas/FasL Genetic Factors Infections Chapter 4Treatment of Autoimmune Disease Section 22Immunodeficiency Diseases Chapter 1Introduction Chapter 2Primary/Congenital Immuno- deficiency Diseases Congenital B Cell ImmunodeficiencyDisorders Congenital T Cell/Cellular Immuno deficiency Disorders Combined Immunodeficiency Disorders Complement Deficiencies Phagocytic Defects Chapter 3Secondary Immunodeficiency HIV and AIDS Chapter 4Treatment of Immunodefici ency Section 23Tumor Immunology Chapter 1Tumor Antigens Classification by Specificity of Antigen Classification by Origin and Nature of Antigen Chapter 2Mechanisms of Antitumor Effects Cellular Immunity Humoral Immunity Chapter 3Mechanisms of Tumor Escape Tumor Cell-Associated Factors Host Immune System-associated Factors Chapter 4Tumor Immunodiagnosis Chapter 5Tumor Immunotherapy Cellular Immunotherapy Humoral Immunotherapy Tumor Vaccines Section 24Transplantation Immunology Chapter 1Immunologic Basis of Allograft Rejection Attributes of Allograft Rejection Target Antigens of Allograft Rejection Cell Basis of Allograft Rejection Recognition of Alloantigens Chapter 2Allograft Rejection Types and Mechanisms HVGR GVHR Chapter 3Prevention and Treatment of Allograft Rejection Donor Selection Immunosuppressive Agents Specific Tolerance to Transplantation Antigens Section 25Immunodiagnosis Chapter 1Detection of Antigens and Antibodies Principles of Antigen-Antibody Reaction Detection of Antigens and Antibodies Chapter 2Detection of Cellular Immunity Lymphocyte Isolation and Phenotyping Lymphocyte Function Assays Phagocyte Function Assays Chapter 3Clinical Analysis of Immune System by Molecular Genetic Techniques Hybridization Polymerase Chain Reaction Genome Sequencing Chapter 4Application of ImmunologicTests Selection and Evaluation of Immune-Tests Clinical Application of Immune-Tests Section 26Immunotherapy Chapter 1Definition and Classification Chapter 2Molecular Immunotherapy Molecular Vaccines Antibody Immunotherapy Cytokine Therapy Microbe Antigen Vaccine Chapter 3Cellular Immunotherapy Adoptive Immunotherapy Stem Cells Transplantation Chapter 4BRMs and Inrramosupressors BRMs Immunosupressor Section 27Immunoprevention Chapter 1Artificial Immunization Artificial Active Immunization Artificial Passive Immunization Planned Immunization Chapter 2Development of New Vaccines Basic Requirements for Vaccines Development of New Vaccines Chapter 3Application of Vaccines Prevention of Infectious Diseases Prevention of Tumor Others Appendix English-Chinese Comparison Attached Compact Discs Animator: Si Chuanping Narrator: Sean Mcnulty (Ireland) Script : Immunoglobulins : Si Chuanping Cytokines : Meng Fanping Major Histocompatible Complex: Ding Jianbing The Mechanism by which Neutrophils engulf and digest microorganisms: Li Jintao Antigen Presentation : Liu Ying T Cell Recognition and Response to Antigens: Zhang Chongjie B Cell Recognition and Response to Antigens: Ji Xiaohui Immunoregulation : Han Mei
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